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KMID : 1145520210070010041
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Journal of Radiopharmaceuticals and Molecular Probes
2021 Volume.7 No. 1 p.41 ~ p.49
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Molecular imaging of polarized macrophages in tumors
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Yoo Ran-Ji
Lee Yun-Sang
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Abstract
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Diversity and flexibility are two typical hallmarks of macrophages. Two types of macrophages, M1(classically activated macrophages) and M2(alternatively activated macrophages) exist at both ends of the commonly known macrophage polarization. M1 macrophages have inflammatory properties and are primarily responsible for defending against invading bacteria in our body. On the other hand, M2 macrophages are involved in antiinflammatory responses and tissue remodeling. Polarized migration of macrophages is of increasing interest in regulating the initiation, generation, and resting phases of inflammatory diseases. In this review, it intend to discuss the properties and functions of tumor-associated macrophages based on polarized macrophages that affect inflammatory diseases. In addition, the purpose of this study is to investigate a molecular imaging approach that targets macrophages that affect tumor growth by controlling the polarization of macrophages that affect tumor diagnosis and treatment.
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KEYWORD
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Macrophage polarization, Tumor-associated macrophage(TAM), Polarized macrophage target imaging
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